MovDisordV3, Main, Exploration, bibRecord, 000A05

Elevated Arteriolar Cerebral Blood Volume in Prodromal Huntington’s Disease

Identifieur interne : 000A05 ( Main/Exploration ); précédent : 000A04; suivant : 000A06

Elevated Arteriolar Cerebral Blood Volume in Prodromal Huntington’s Disease

Auteurs : Jun Hua [États-Unis] ; Paul G. Unschuld [États-Unis, Suisse] ; Russell L. Margolis [États-Unis] ; Peter C. M. Van Zijl [États-Unis] ; Christopher A. Ross [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.

RBID : PMC:3834086

English descriptors

KwdEn :
- Adult, Aged, Atrophy (pathology), Biological Markers (blood), Blood Volume (physiology), Female, Humans, Huntington Disease (blood), Huntington Disease (pathology), Magnetic Resonance Imaging (methods), Male, Middle Aged, Pilot Projects.
MESH :
- chemical , blood : Biological Markers.
- blood : Huntington Disease.
- methods : Magnetic Resonance Imaging.
- pathology : Atrophy, Huntington Disease.
- physiology : Blood Volume.
- Adult, Aged, Female, Humans, Male, Middle Aged, Pilot Projects.

Abstract

Background

Neurovascular alterations have been implicated in the pathophysiology of Huntington’s Disease (HD). As arterioles are most responsive to metabolic alterations, arteriolar-cerebral-blood-volume (CBV_a) is an important indicator of cerebrovascular regulation. This pilot study is intended to investigate potential neurovascular (CBV_a) abnormality in prodromal-HD, and compare it with the widely used imaging marker brain atrophy.

Methods

CBV_a and brain volumes were measured with ultra-high field (7T) magnetic-resonance-imaging in seven prodromal-HD patients and nine age-matched controls.

Results

Cortical CBV_a was significantly elevated in prodromal-HD patients (relative difference=38.5%, effect size=1.48). Significant correlations were found between CBV_a in frontal cortex and genetic measures. By contrast, no significant brain atrophy was detected in these prodromal-HD patients.

Conclusions

CBV_a may be abnormal in prodromal-HD, even before substantial brain atrophy occurs. Further investigation with a larger cohort and longitudinal follow-up is merited to determine whether it could be used as a potential biomarker for clinical trials.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834086

DOI: 10.1002/mds.25591
PubMed: 23847161
PubMed Central: 3834086

Affiliations:

Le document en format XML

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<author><name sortKey="Van Zijl, Peter C M" sort="Van Zijl, Peter C M" uniqKey="Van Zijl P" first="Peter C. M." last="Van Zijl">Peter C. M. Van Zijl</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Elevated Arteriolar Cerebral Blood Volume in Prodromal Huntington’s Disease</title>
<author><name sortKey="Hua, Jun" sort="Hua, Jun" uniqKey="Hua J" first="Jun" last="Hua">Jun Hua</name>
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<author><name sortKey="Margolis, Russell L" sort="Margolis, Russell L" uniqKey="Margolis R" first="Russell L." last="Margolis">Russell L. Margolis</name>
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<author><name sortKey="Van Zijl, Peter C M" sort="Van Zijl, Peter C M" uniqKey="Van Zijl P" first="Peter C. M." last="Van Zijl">Peter C. M. Van Zijl</name>
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<author><name sortKey="Ross, Christopher A" sort="Ross, Christopher A" uniqKey="Ross C" first="Christopher A." last="Ross">Christopher A. Ross</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neuroscience and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
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<term>Biological Markers (blood)</term>
<term>Blood Volume (physiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Huntington Disease (blood)</term>
<term>Huntington Disease (pathology)</term>
<term>Magnetic Resonance Imaging (methods)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pilot Projects</term>
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<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biological Markers</term>
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</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Atrophy</term>
<term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Volume</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pilot Projects</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Neurovascular alterations have been implicated in the pathophysiology of Huntington’s Disease (HD). As arterioles are most responsive to metabolic alterations, arteriolar-cerebral-blood-volume (CBV<sub>a</sub>
) is an important indicator of cerebrovascular regulation. This pilot study is intended to investigate potential neurovascular (CBV<sub>a</sub>
) abnormality in prodromal-HD, and compare it with the widely used imaging marker brain atrophy.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">CBV<sub>a</sub>
 and brain volumes were measured with ultra-high field (7T) magnetic-resonance-imaging in seven prodromal-HD patients and nine age-matched controls.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Cortical CBV<sub>a</sub>
 was significantly elevated in prodromal-HD patients (relative difference=38.5%, effect size=1.48). Significant correlations were found between CBV<sub>a</sub>
 in frontal cortex and genetic measures. By contrast, no significant brain atrophy was detected in these prodromal-HD patients.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">CBV<sub>a</sub>
 may be abnormal in prodromal-HD, even before substantial brain atrophy occurs. Further investigation with a larger cohort and longitudinal follow-up is merited to determine whether it could be used as a potential biomarker for clinical trials.</p>
</sec>
</div>
</front>
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<name sortKey="Hua, Jun" sort="Hua, Jun" uniqKey="Hua J" first="Jun" last="Hua">Jun Hua</name>
<name sortKey="Margolis, Russell L" sort="Margolis, Russell L" uniqKey="Margolis R" first="Russell L." last="Margolis">Russell L. Margolis</name>
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<name sortKey="Ross, Christopher A" sort="Ross, Christopher A" uniqKey="Ross C" first="Christopher A." last="Ross">Christopher A. Ross</name>
<name sortKey="Ross, Christopher A" sort="Ross, Christopher A" uniqKey="Ross C" first="Christopher A." last="Ross">Christopher A. Ross</name>
<name sortKey="Ross, Christopher A" sort="Ross, Christopher A" uniqKey="Ross C" first="Christopher A." last="Ross">Christopher A. Ross</name>
<name sortKey="Unschuld, Paul G" sort="Unschuld, Paul G" uniqKey="Unschuld P" first="Paul G." last="Unschuld">Paul G. Unschuld</name>
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<name sortKey="Van Zijl, Peter C M" sort="Van Zijl, Peter C M" uniqKey="Van Zijl P" first="Peter C. M." last="Van Zijl">Peter C. M. Van Zijl</name>
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<country name="Suisse"><region name="Canton de Zurich"><name sortKey="Unschuld, Paul G" sort="Unschuld, Paul G" uniqKey="Unschuld P" first="Paul G." last="Unschuld">Paul G. Unschuld</name>
</region>
</country>
</tree>
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Movement Disorders (revue)

Elevated Arteriolar Cerebral Blood Volume in Prodromal Huntington’s Disease

Elevated Arteriolar Cerebral Blood Volume in Prodromal Huntington’s Disease

Source :

English descriptors

Abstract

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	Movement Disorders (revue)
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